An example of this is the test at fast/regions/inline-block-inside-anonymous-overflow-with-covered-controls.html. Look at this test compared to fast/regions/inline-block-inside-anonymous-overflow-with-covered-controls-expected.html in Safari (not in DRT since this test turns of modern media controls) and see the slight difference in positioning. This appears to be compositing-related since turning off the play button as a layer positions it correctly and getBoundingClientRect() doesn't return differences in layout between the two files.
<rdar://problem/30691740>
This started happening after https://bugs.webkit.org/show_bug.cgi?id=168800 which made the problem evident.