http://trac.webkit.org/changeset/51158 added ASSERT(isMainThread()) to TreeShared methods. This practically didn't slow down debug build on Mac and Windows, but on Chromium some layout tests started to timeout. For example, editing/selection/extend-selection.html execution time grew 15 times (!). This test operates with selection and it does a lot of operations like Position::previous() that churns refcout on Nodes. Turned out the isMainThread() on pthread-based Chromium (Mac and Linux) involves mapping through threadMap, which in turn takes 2 Mutexes to lock - in identifierByPthreadHandle() and in iterator code. By comparing handle itself rather then mapped Id the time required by isMainThread() goes back to reasonable. Patch is coming.
Created attachment 43530 [details] Proposed patch.
Comment on attachment 43530 [details] Proposed patch. I wonder why you chose to rename the variable to mainThreadHandle. Mac man page for pthread_self says "returns the thread ID of the calling thread". Of course, "identifier" is taken already, but it's not a handle either.
Landed: http://trac.webkit.org/changeset/51211