While browsing some pages (usually image galleries heaving lots of images), i get "Operation Could Not Be Completed: Too Many Open files error" and some images or other elements don't load. This happens usually with pages using css for image resizing for a high number of images. Quitting Safari and opening a new session solves the problem. Sample page: http://film.com.tr/star/index.cfm
A support post about the same problem: http://discussions.apple.com/thread.jspa?messageID=9145976
When you get in to this situation, can you please run Activity Monitor, double-click on Safari, select Open Files and Ports, copy the list of files in to a text file, then attach it to this bug.