On my Fedora 33 laptop with Intel Sandybridge graphics, under Xorg/X11 (didn't test Wayland) and Epiphany 3.38.x (with WebKitGTK 2.30.5), opening https://twitter.com/aperezdc in any epiphany window* and scrolling with either the touchpad or the mousewheel, it is extremely slow, as in, roughly 2 to 3 frames per second. Yet I don't think Adrián's tweets are that heavy. I'd try with Epiphany tech preview as well, but currently it is utternly broken and unable to load any pages (I get "(epiphany:2): epiphany-WARNING **: 20:32:31.926: Web process crashed" spammed in the terminal when running it) *: it happens in any regular epiphany window (no need for app mode), including a regular private window. For testing's sake, it's easier / more standardized for me to just use a private navigation window for this.
Unable to reproduce in GNome Web 44.2/ WebKitGTK 2.40.1. Perhaps fixed already?