Created attachment 410135 [details] reproduction.html Open https://jsfiddle.net/nt75w0zx/1/ on Safari 14 (on the latest iPadOS 14 in my case) and any desktop/mobile Chrome/Firefox/IE11 => On other browsers both "Hello1!" and "Hello2!" are aligned, on Safari 14 "Hello1!" is lower than "Hello2!".
Created attachment 410137 [details] safari14 screenshot
Created attachment 410138 [details] chrome screenshot
<rdar://problem/69849257>
This was fixed by a change somewhere in this range: https://trac.webkit.org/log/webkit/trunk?mode=follow_copy&rev=268844&stop_rev=268785