If you go to outlook.com and log in, the page will not respond. Your inbox will load correctly, but clicking on email messages does nothing. I have verified outlook.com works correctly in webkitgtk 2.0.4 but does not work in 2.2.1. I am bisecting now to find the problem, and I will update this page as I narrow it down.
After spending many days bisecting, here is where I am. Revision 153000 works correctly on outlook.com. webkitgtk v2.1.90 does not work for outlook.com. That release is revision 154696. However, I have also tested revision 153500 and 153400. Both of those build, but crash shortly after loading pages. It looks to be a javascript issue. I can only see outlook.com for a few seconds before it crashes. During that time, it behaves like the versions that do not work.
I have found that this error is caused by this bug: https://bugs.webkit.org/show_bug.cgi?id=120080 However, the patch landed as a result of that bug doesn't totally fix outlook.com. The page will respond to clicks, but will crash after a few seconds. I have tested current revisions, and the problem is eventually fixed. As far as making webkitgtk 2.2.x work, setting the environment variable JSC_useJIT=false on the process gets outlook.com working with no crashes.